I need everyone's help in spreading this information.
I was diagnosed with CML (Chronic Myelogenous Leukemia) in August of 2015. As soon as I found out that I had it, I began reading everything I could on it, Scientific articles, new medications, trials, everything. In 2018 I stumbled upon a researcher who was testing drug combinations which showed that LSC's (Leukemic Stem Cells) were eliminated in lab mice. LSC's are NOT targeted by any of the medications on the market today, it is my theory that this was by design. By keeping the LSC's alive, a patient is forced to take the treatment drug for their entire life, and that drug costs upwards of $180,000 per year. Below is my story of how I cured myself of this incurable disease.
How I CURED My CML
I'm almost 99.9% confident it is cured, the combination of a TKI (Tyrosine Kinase Inhibitors) + Misoprostol (a common drug used for ulcers and to terminate pregnancies) works. I've been non-detectable for years, in 2022 I began lowering my dosage, first to 300 mg and then to 200 mg and now at 0 mg. My doctor doesn't really know it, but I've been basically drug free since I took a trip to Belize in the summer of 2022, been completely off of TKI's (officially, which doctor knows about) since February, doing monthly tests and non-detectable. Am I 100% certain all stem cells are gone? Nope, without a Star Trek type tricorder no one can ever be, as you would need to check every cell in the body for the mutation.
I'm not selling anything but the truth, the scientist who came up with this information (his research and name are linked in the post below) has not been able to get any funding for this as the profit motive in our Capitalist system seems to only care about treatments which are far more profitable than cures. I hate money and the profit motive, the removal of needless suffering is what motivates me, and I need people to spread this information far and wide otherwise it will never get out there.
What I recommend is your regular dosage of TKI (mine was 400 mg Imatinib) + 800 mcg Misoprostol, I did take 1600 mcg a few times, but it isn't pleasant. The pills themselves taste like crap, get stuck in your mouth and are hard to wash down, making the experience even worse. I don't recommend taking unless you plan to be home the next day (I took mine every night) as the diarrhea from the combination is pretty bad. If you are below MMR (DMR or non-detectable is probably safest), you can also try pulsing; take the combo one day, then take the next 2 to 3 days off completely, then take the combo again, repeat. I do believe that this helped in eliminating the LSC's.
This is not a one time cure, it took me many years to do so. I linked the beginning of my journey below as it has far more details. You might hit non-detectable in a few months like I did and be tempted as I was to try to stop on your own. Don't do it! Keep non-detectable and continue taking both medicines (as much as you can tolerate) until you're non-detectable for two years, then try dosage reduction and stopping.
Getting a prescription for Misoprostol might be the biggest hurdle, but my doctor was fine with me testing the combination on myself, so I got lucky. You may need to go through other channels.
Please send this to everyone you know, it's not going to get out there through the media and I don't expect any trials either, it could save someone's life.
The beginning of my journey:
Non-Detectable (0.000%) and potential cure for CML
Received my test results yesterday evening and finally hit ND (0.000%) after 3 years and 9 months.
Results of all tests since diagnosis:
I want to highlight two area in the above chart, the first is in italics from 03/05/2018 through 06/05/2018. There was a slight bump up during this period and then a large drop (MMR to CMR) afterwards, the reason for this may have been due to an experiment my doctor and I tried. I stopped taking the experimental medication after the drop to CMR (due to side effects) and stayed stable at CMR for the next two testing cycles.
The next change is underlined in the chart above dated 12/03/2018 through 06/10/2019. After the 12/03 test I decided to go back to trying the experimental medication once again and did so for about two months during that window and the result was Non-Detectable. A few notes about this six month time period:
- My daughter was put in preschool during this time and was always getting sick which of course resulted in me becoming sick. I missed a lot of doses of medicine during those sick periods and also missed my dose the night before my blood test (forgot). I would say that overall, I likely missed about 20 doses during that time.
- I took the experimental medication around the March and April time frames and stopped taking it once again due to the side effects.
Drug Details
Medication: Misoprostol
Dose: 200 mcg
Availability: Prescription only (yes, it is and has been widely available for some time)
Details of when and how much I was taking and the side effects:
03/05/2018 through 06/05/2018 (began in February, ended in April)
1 times daily, 4 x 200 mcg at the same time as taking Imatinib dose (nightly, before bed).
12/03/2018 through 06/10/2019 (began in March, ended in April)
1 times daily, 8 x 200 mcg at the same time as taking Imatinib dose (nightly, before bed).
The typical dosage is to take one 200 mcg tablet (if you can call it that) every four hours. This is the standard dosage for people with ulcer problems. This medication is also used for abortions (in a higher does, which happens to be 1600 mcg which I was taking later on). Since I was not taking the medicine for ulcers, I decided to take the four doses (later eight) all at the same time as my Imatinib to increase the chance of it working.
Side effects:
Serious bouts of diarrhea (far more serious than with Imatinib). I eventually stopped taking it on nights before I had to work the next day and only took the Misoprostol if I knew I was going to be home the next day.
Bouts of dizziness. I am not 100% certain this was from the Misoprostol or the blood pressure medication I was also taking at the same time. The blood pressure medication (Losartan - HCTZ 50-12.5 mg) does have an interaction with Imatinib and I stopped taking it around the same time as I stopped taking the Misoprostol. I intend to take the Misoprostol again in the future and will update with any results.
So why Misoprostol?
It all began almost two years ago when I stumbled on an article (https://www.news-medical.net/news/20170926/Existing-drugs-may-be-able-to...) which made mention of two drugs which were currently available possibly being used to cure CML by eradicating the CML stem cells. I investigated the two medications and found Misoprostol to be the safer of the two. I inquired the possibility of testing this out with my Oncologist and he prescribed three months worth of the medication to me.
https://www.ncbi.nlm.nih.gov/pubmed/28844837
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678929/
Now, there is no guarantee that this works, maybe my test results were just pure chance, maybe not, but after having been stuck at MMR for such a long time and reaching CMR (and DMR) after taking the Misoprostol, well, a sample size of one is not going to cut it so thought the best course of action would be to share these results with others. I do not know if your doctor will be as willing to try this as mine was and prescribe a medication used to treat ulcers to treat your CML but I would hope that they might.
I am going to continue to take my medication and try the Misoprostol from time to time. I will also be looking to try TFR to see if this truly did work or not but likely will not attempt it until September or later.
Edit: The table feature does not work so had to create an image, store it on my blog and link it here. If you cannot view the image, let me know.
Full post including replies here:
https://cmlsupport.org.uk/thread/13139/non-detectable-0000-and-potential-cure-cml#post-56873
