How I CURED My CML (Chronic Myelogenous Leukemia)

I need everyone's assistance in sharing this crucial information.

In August 2015, I received a diagnosis of CML (Chronic Myelogenous Leukemia). The moment I learned about my condition, I dove deep into research, studying scientific papers, new treatments, clinical trials, and everything available. During 2018, I discovered a researcher testing drug combinations that successfully eliminated LSC's (Leukemic Stem Cells) in laboratory mice. Current medications on the market don't target these LSC's, and I believe this omission is intentional. By allowing LSC's to survive, patients must continue treatment for life, with these drugs costing over $180,000 annually. What follows is my personal account of overcoming this supposedly incurable condition.

How I CURED My CML

Update: My latest test results from earlier this year confirm I remain Not Detectable (ND). This combination therapy has truly proven effective.

I'm nearly 99.9% certain the disease is cured - the combination of TKI (Tyrosine Kinase Inhibitors) plus Misoprostol (commonly prescribed for ulcers and pregnancy termination) is effective. I've maintained non-detectable levels for years. In 2022, I started reducing my dosage from 300 mg to 200 mg, and eventually to 0 mg. While my physician isn't fully aware, I've been essentially medication-free since my Belize trip in summer 2022, and completely off TKIs (officially known to my doctor) since February 2023, with monthly testing showing non-detectable results. Am I absolutely certain every stem cell is eliminated? No, without futuristic scanning technology, complete certainty is impossible since it would require examining every body cell for the mutation.

I'm not promoting any product except truth. The scientist behind this research (whose work and identity are referenced below) cannot secure funding because our capitalist healthcare system prioritizes profitable treatments over cures. I despise the money-driven approach - eliminating unnecessary suffering drives me, and I need people to share this information widely or it will remain hidden.

My recommendation is your standard TKI dosage (mine was 400 mg Imatinib) plus 800 mcg Misoprostol. I occasionally took 1600 mcg, but it's quite unpleasant. The tablets taste awful, stick in your mouth, and are difficult to swallow. I suggest taking them only when you can stay home the following day (I took mine nightly) because the combination causes severe diarrhea. If you're below MMR (DMR or non-detectable is probably safest), consider pulsing: take the combination one day, then skip 2-3 days completely, then repeat. I believe this approach helped eliminate the LSC's.

This isn't an instant cure - it required many years for me. I've linked my journey's beginning below with additional details. You might achieve non-detectable status in months like I did and feel tempted to stop independently. Resist this urge! Maintain non-detectable levels and continue both medications (as tolerated) until you're non-detectable for two years, then attempt dosage reduction and cessation.

Obtaining a Misoprostol prescription might be your biggest challenge, though my physician supported my self-experimentation, so I was fortunate. You may need alternative approaches.

Please share this with everyone you know - it won't reach people through mainstream media and I don't anticipate any trials, but it could save lives.

The beginning of my journey:

Non-Detectable (0.000%) and potential cure for CML

I received my test results yesterday evening and finally achieved ND (0.000%) after 3 years and 9 months.

Complete test results since diagnosis:

I want to emphasize two periods in the chart above. First, the italicized section from 03/05/2018 through 06/05/2018 shows a slight increase followed by a significant drop (MMR to CMR). This change may have resulted from an experiment my doctor and I attempted. I discontinued the experimental medication after reaching CMR (due to side effects) and remained stable at CMR for the next two testing cycles.

The second change is underlined, dated 12/03/2018 through 06/10/2019. Following the 12/03 test, I resumed the experimental medication for approximately two months within that timeframe, resulting in Non-Detectable status. Several notes about this six-month period:

• My daughter started preschool and frequently became ill, which naturally made me sick too. I missed numerous medication doses during these illness periods and also forgot my dose the night before blood testing. Overall, I probably missed around 20 doses during this time.

• I took the experimental medication around March and April, stopping again due to side effects.

Drug Details

Medication: Misoprostol

Dose: 200 mcg

Availability: Prescription required (widely available for some time)

Timing, dosage, and side effects details:

03/05/2018 through 06/05/2018 (started February, ended April)

Once daily, 4 x 200 mcg tablets taken simultaneously with Imatinib dose (nightly, before bed).

12/03/2018 through 06/10/2019 (started March, ended April)

Once daily, 8 x 200 mcg tablets taken simultaneously with Imatinib dose (nightly, before bed).

Standard dosage involves taking one 200 mcg tablet every four hours for ulcer treatment. This medication is also used for pregnancy termination (at higher doses, specifically 1600 mcg which I later used). Since I wasn't treating ulcers, I chose to take all four doses (later eight) together with my Imatinib to maximize effectiveness.

Side effects:

Severe diarrhea episodes (much worse than with Imatinib alone). I eventually avoided taking it before work days and only used Misoprostol when I could stay home the next day.

Dizzy spells. I'm uncertain whether this resulted from Misoprostol or the blood pressure medication I was simultaneously taking. The blood pressure drug (Losartan - HCTZ 50-12.5 mg) does interact with Imatinib, and I stopped both medications around the same time. I plan to try Misoprostol again and will share any updates.

So why Misoprostol?

This journey began sometime in 2018 when I found an article (https://www.news-medical.net/news/20170926/Existing-drugs-may-be-able-to...) mentioning two currently available drugs potentially capable of curing CML by destroying CML stem cells. I researched both medications and determined Misoprostol was the safer option. I discussed testing this possibility with my Oncologist, who prescribed three months' worth of medication.

https://www.ncbi.nlm.nih.gov/pubmed/28844837

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678929/

While there's no guarantee this approach works - perhaps my results were coincidental - after being stuck at MMR for an extended period and achieving CMR (and DMR) following Misoprostol use, I felt compelled to share these findings. A single case isn't sufficient evidence, so sharing these results with others seemed like the right course of action. I don't know if your doctor will be as open to prescribing an ulcer medication for CML treatment as mine was, but I hope they might consider it.

I have not taken any medication since 2023, and really stopped in 2022 as I was taking it very rarely. The TFR attempt was successful, confirming this truly worked.

Edit: The table feature didn't work, so I created an image, stored it on my blog, and linked it here. If you can't view the image, please let me know.

Complete post with replies here:

https://cmlsupport.org.uk/thread/13139/non-detectable-0000-and-potential-cure-cml#post-56873